Sickle cell disease is the most common of the hereditary blood disorders. It occurs almost exclusively among black Americans and black Africans. Sickle cell disease in black Americans occurs in 3 of every 1,000 (or about 1 in 375) live births. Estimates indicate that the severe form of sickle cell disease affects more than 50,000 black Americans.

The man have “shortness of breath, palpitations, and episodes of icterus [yellow eyes]. He had an anemia.” Dr. Herrick described the patient’s blood smear as showing “thin, sickle-shaped and crescent-shaped red cells.”

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